Scientific evidences supporting the fit4Pandemic project

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Arash Asher, Nathan L. Tintle, Michael Myers, Laura Lockshon, Heribert Bacareza, and William S. Harris
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Giuseppe Cerullo, Massimo Negro, Mauro Parimbelli, Michela Pecoraro, Simone Perna, Giorgio Liguori, Mariangela Rondanelli, Hellas Cena and Giuseppe D’antona
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Università di Pavia
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Arinjay Banerjee, Michelle L. Baker, Kirsten Kulcsar, Vikram Misra, Raina Plowright and Karen MossmanTherapeutic options in response to the 2019-nCoV outbreak are urgently needed. Here, we discuss the potential for repurposing existing antiviral agents to treat 2019-nCoV infection (now known as COVID-19), some of which are already moving into clinical trials.
L’organismo produce una sostanza biochimica naturale con potere antivirale denominata PGA 1. Per combattere un’infezione è necessario che i suoi livelli siano il più possibile elevati. Infatti bassi livelli di PGA 1 favoriscono l’azione del virus influenzale e di tutti i tipi di virus. Poichè non si possono assumere integratori a base di PGA 1, l’unico modo di aumentarne i livelli è aumentare l’assunzione di Omega 3. Gli Omega 3 infatti…..
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La Polidatina, derivato naturale dell’Anti-ossidante resveratrolo (quello presente, ad esempio nel vino rosso rendendone utile il consumo a dosi moderate per la prevenzione delle malattie cardio-vascolari), raggiunge tutte le cellule dei tessuti in concentrazione molto elevate ed attive. In particolare migliora…..
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The epidemiology of influenza swarms with incongruities, incongruities exhaustively detailed by the late British epidemiologist, Edgar Hope-Simpson. He was the first to propose a parsimonious theory explaining why influenza is, as Gregg said, “seemingly unmindful of traditional infectious disease behavioral patterns.” Recent discoveries indicate vitamin D upregulates the endogenous antibiotics of innate immunity and suggest that the incongruities explored by Hope-Simpson may be secondary to the epidemiology of vitamin D deficiency. We identify…..
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John J Cannell, Michael Zasloff, Cedric F Garland, Robert Scragg, and Edward Giovannucci
Genes required for SARS-CoV-2 entry into human cells, ACE2 and FURIN, were employed as baits to build genomic-guided molecular maps of upstream regulatory elements, their expression and functions in the human body, and pathophysiologically relevant cell types. Repressors and activators of the ACE2 and FURIN genes were identified based on the analyses of gene silencing and overexpression experiments as well as relevant transgenic mouse models. Panels of repressors (VDR; GATA5; SFTPC; HIF1a) and activators (HMGA2; INSIG1; RUNX1; HNF4a; JNK1/c-FOS) were then employed to identify existing drugs manifesting in their effects on gene expression signatures of potential coronavirus infection mitigation agents. Using this strategy, vitamin D and quercetin have been identified as putative 2019 coronavirus disease (COVID-19) mitigation agents. Quercetin has been identified as one of top-scoring candidate therapeutics in the supercomputer SUMMIT drug-docking screen and Gene Set Enrichment Analyses (GSEA) of expression profiling experiments (EPEs), indicating that highly structurally similar quercetin, luteolin, and eriodictyol could serve as scaffolds for the development of efficient inhibitors of SARS-CoV-2 infection. In agreement with this notion, quercetin alters the expression of 98 of 332 (30%) of human genes encoding protein targets of SARS-CoV-2, thus potentially interfering with functions of 23 of 27 (85%) of the SARS-CoV-2 viral proteins in human cells. Similarly, Vitamin D may interfere …..
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The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a devastating event that is causing thousands of victims every day around the world. One of the main reasons of the great impact of coronavirus disease 2019 (COVID-19) on society is its unexpected spread, which has not allowed an adequate preparation. The scientific community is fighting against time for the production of a vaccine, but it is difficult to place a safe and effective product on the market as fast as the virus is spreading. Similarly, for drugs that can directly interfere with viral pathways, their production times are long, despite the great efforts made. For these reasons, we analyzed the possible role of non-pharmacological substances such as supplements, probiotics, and nutraceuticals in reducing the risk of Sars-CoV-2 infection or mitigating the symptoms of COVID-19. These substances could have numerous advantages in the current circumstances, are generally easily available, and have negligible side effects if administered at the already used and tested dosages. Large scientific evidence supports the benefits that some …..
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Fabio Infusino ,Massimiliano Marazzato,Massimo Mancone ,Francesco Fedele ,Claudio Maria Mastroianni Paolo Severino ,Giancarlo Ceccarelli ,Letizia Santinelli ,Elena Cavarretta ,Antonino G. M. Marullo ,Fabio Miraldi, Roberto Carnevale ,Cristina Nocella ,Giuseppe Biondi-Zoccai ,Cristiano Pagnini,Sonia Schiavon ,Francesco Pugliese ,Giacomo Frati and Gabriella d’Ettorre
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NEWS
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Oliver J McElvaneya, Brian D Hobbsc, Dandi Qiaoc, Oisín F McElvaneya, Matthew Mollc,Natalie L McEvoye, Jennifer Clarkeb, Eoin O’Connorb, Sean Walsh, Michael H Choc, Gerard F Curleyb, Noel G McElvaneya
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Alai Tana, Brent Sullenbargera, Ruchika Prakashb, Jodi C. McDaniela
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Charles N. Serhan, Bruce D. Levy
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NEWS
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NEWS
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NEWS